March 11th, 2022
Canadian Ophthalmological Society (COS)and Canadian Retina Society (CRS) Joint Position Statement on Polysulfate Sodium (Elmiron)
Pentosan Polysulfate sodium (PPS), also known as Elmiron, is an oral medication prescribed for the treatment of interstitial cystitis (IC). PPS has been used to treat IC since 1996.
A dose-related progressive retinal maculopathy is associated with the use of PPS. The retinal changes from PPS include macular edema, choroidal neovascularization and retinal pigment epithelial hyperpigmentation followed by atrophy. Severe vision loss is associated with late PPS maculopathy.